Isolation of isoflavonoids possessing antioxidant activity from the fermentation broth of Streptomyces sp.

نویسندگان

  • K Komiyama
  • S Funayama
  • Y Anraku
  • A Mita
  • Y Takahashi
  • S Omura
  • H Shimasaki
چکیده

Three antioxidant isoflavonoids characterized as 4',7,8-trihydroxyisoflavone (1), 3',4',7-trihydroxyisoflavone (2) and 8-chloro-3',4',5,7-tetrahydroxyisoflavone (3) were isolated from the cultured broth of Streptomyces sp. OH-1049. Among them, 3 is a novel isoflavonoid possessing a chlorine atom in the molecule. In in vitro studies, these antibiotics were found to possess antioxidant activity whereas showed almost no cytocidal activities against HeLa S3 cells.

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منابع مشابه

Structural study of isoflavonoids possessing antioxidant activity isolated from the fermentation broth of Streptomyces sp.

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 42 9  شماره 

صفحات  -

تاریخ انتشار 1989